Potential Role of the Microbiome- Endocannabinoidome Connection in the Gut-Brain Axis After Traumatic Brain Injury and Its Association with Alzheimer's Disease
Abstract
Based on published preclinical, clinical, and epidemiological data, we hypotesised that the gut-brain axis and the connection with the endocannabinoidome may peripherally influence the physiopathology of TBI and the subsequent risk of latent neurodegenerative diseases.Therefore, the objective of this research is to investigate the effects of a mild TBI on the subsequent development of Alzheimer's disease-related neuropathology and cognitive impairments in an APP/PS1 mice, the role of inflammation, the potential perturbation of the gut microbiome and how the potential alteration in gut microbiota composition may determine the severity of these disorders by regulating the activity of endocannabinoid and related mediators using a multidisciplinary approach. To date, our data in control mice confirm previous studies showing that the mTBI induces a induces a characteristic dual behavioral phenotype (aggressive/depressive) in mice In addition, we demonstrate that mTBI causes significant impairments in the discriminative and spatial memory tasks.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2022
- Accession Number
- AD1193685
Entities
People
- Fabiana Piscitelli
Organizations
- Istituto di Chimica Biomolecolare