Suppression of GWVI Toxin-Activated Microglia and Pathologies by DREADD

Abstract

Approximately one third of Veterans who served in the Gulf War later developed a chronic multi-symptom illness known as Gulf War Illness (GWI). While the exact cause is unknown, it is believed that persistent exposure to environmental toxins such as pesticides and chemical warfare agents may have interacted with combat-related stress to produce lasting neurological and psychiatric complications among this Veteran population. Neuroinflammation has been increasingly linked with psychiatric and neurological disorders and may play a role in GWI pathology. Microglia are a key mediator of neuroinflammation and the underlying goal of this project is to test the hypothesis that microglial activation acts as a causal factor to produce cognitive and psychiatric disturbances in a mouse model of GWI. In particular, this project will utilized novel Designer Receptors Exclusively Activated by Designer Drugs (DREADD) technology to inactivate microglia in our mouse model of GWI.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2022
Accession Number
AD1194083

Entities

People

  • Giulio Maria Pasinetti

Organizations

  • Icahn School of Medicine at Mount Sinai

Tags

DTIC Thesaurus Topics

  • Animal Behavior
  • Biomedical Research
  • Blood
  • Cells
  • Chemical Warfare
  • Chemical Warfare Agents
  • Department Of Defense
  • Dermatologic Agents
  • Designer Drugs
  • Diseases
  • Electronic Mail
  • Experimental Design
  • Gene Expression
  • Genes
  • Maryland
  • Medical Personnel
  • Neuroglia
  • New York
  • Pathology
  • Persian Gulf Syndrome
  • Rna Sequence Analysis
  • Standards
  • Technology Transfer

Fields of Study

  • Psychology

Readers

  • Gulf War Illness and Chronic Multisymptom Illness in Veterans.
  • Immunology and Pathology