Therapeutic Targeting of FLCN-Deficient Renal Cancers
Abstract
The goals of this proposal are: 1) to identify the cellular phospho-proteome regulated by FLCN, 2) to discover the mechanisms by which FLCN suppresses the non-canonical translational initiation of a specific subset of mRNAs, and 3) to assign FLCN functions to specific protein domains. So far we profiled the cellular proteome changes regulated by FLCN in vitro and we gained major insights into the mechanism by which FLCN regulates protein translation.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2022
- Accession Number
- AD1194087
Entities
People
- Othon Iliopoulos
Organizations
- Massachusetts General Hospital