A Dual Antibiotic-Steroid Drug-Eluting Contact Lens for Treatment of Eye Injuries That Can Be Used in an Austere Environment or Prolonged Field Care Setting

Abstract

We have developed a therapeutic contact lens that releases BOTH a broad spectrum antibiotic (moxifloxacin [MXF]) and a steroid (dexamethasone [DEX]). The drug-eluting contact lens consists of a thin drug-polymer film encapsulated within the periphery of a standard contact lens. Importantly, the MXF-DEX TCL is available for immediate On-Demand use. We achieved this significant advantage over the prior approach by using a nondegradable polymer to help modulate the drug release. The non-degradable polymer allows the lenses to be stored for 1-2 years at room temperature in a hydrated state within a blister pack or bottle. This application will test MXF-DEX TCLs in both infectious and inflammatory animal model.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2022
Accession Number
AD1194091

Entities

People

  • Joseph B Ciolino

Organizations

  • Schepens Eye Research Institute

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DTIC Thesaurus Topics

  • Abstracts
  • Biomedical Research
  • Boundaries
  • Corneal Diseases
  • Department Of Defense
  • Electronic Mail
  • Environment
  • Experimental Design
  • Eye Injuries
  • Information Operations
  • Instructions
  • Law
  • Maryland
  • Medical Personnel
  • New Zealand
  • Patent Applications
  • Polymeric Films
  • Professional Development
  • Standards
  • Technology Transfer
  • Test And Evaluation

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  • Nanocomposite Materials Science
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  • Toxicology/Environmental Toxicology