Fusogen Nanomedicine for Peripheral Nerve Repair

Abstract

This project is directed at the PRMRP Focus Area of development of novel therapies to repair neurosensory damage. The project deliverables are fusogenic nanoparticles (FNPs), comprised of polymeric fusogens (biomaterials that enhance cell membrane fusion) and cholesterol, to synergistically repair injured peripheral nerves. The central hypothesis being tested is that structure-function relationships among novel amphiphilic tyrosine-derived block copolymer surfactants (TyPS) can lead to effective FNPs which will allow immediate re-establishment of axonal continuity and function.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2023
Accession Number
AD1194120

Entities

People

  • Antonio Merolli
  • Cemile Bektas
  • Daniel Chakhalian
  • David I. Devore
  • Dongming Sun
  • Joseph M. Rosen
  • Kim-phoung Le
  • Mariana Lima
  • Wise Young
  • Yong Mao

Organizations

  • Rutgers University–New Brunswick

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Alkenes
  • Block Copolymers
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Cholesterol
  • Copolymers
  • Department Of Defense
  • Hydrophilic Properties
  • Hydrophobic Properties
  • Liquid Chromatography
  • Measurement
  • Medical Personnel
  • Membrane Lipids
  • Molecular Weight
  • Neurons
  • Particle Size
  • Peripheral Nervous System
  • Polymers
  • Self Assembly
  • Thermodynamic Properties

Readers

  • Nanocomposite Materials Science
  • Neuroscience
  • Neurotrauma and Rehabilitation Medicine.

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech
  • Microelectronics