Cell-Specific microRNA Regulation of Ventilation-Induced Lung Injury during Hemorrhagic Shock
Abstract
The acute respiratory distress syndrome (ARDS) is a life-threatening condition that affects critically ill patients, especially soldiers who develop hemorrhagic shock (HS). Although these patients frequently require life support with mechanical ventilation (MV), the mechanical forces generated during ventilation can cause de novo injury known as ventilator induced lung injury (VILI). Since the molecular mechanisms responsible for VILI are not known, there are presently no effective pharmacological therapies for HS induced ARDS. Recently, microRNAs (miRNAs) have emerged as important small molecule regulators of gene expression and several miRNAs (miR-146a and miR-155) are dysregulated during ARDS. However, it is not known if therapeutic modulation miR-146a or miR-155 expression can be used to regulate the mechanotransduction processes that lead to VILI. The overall goal of this proposal is to demonstrate the therapeutic potential of miR-146a and miR-155in reducing VILI in HS induced ARDS.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2022
- Accession Number
- AD1194696
Entities
People
- Samir N. Ghadiali
Organizations
- Ohio State University