Malignant Changes in Bladder Cancer Associated with Defoliant Exposure

Abstract

Bladder cancer is a common solid tumor in the VA Health System. The Institute of Medicine acknowledged that defoliants such as Agent Orange and Agent Blue used in Vietnam Era conflicts can potentially increase risk of bladder cancer. The active agents in these compounds (2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in Agent Orange and arsenicals/arsenic in Agent Blue) and are known to induce changes in gene expression pathways that can transform cells. We hypothesize that AO/AB exposure causes unique alterations in gene expression and methylation in the urothelium which contribute to malignant degeneration. The objective of this study is to define alterations that occur in the urothelium with exposure to AO/AB in both laboratory models and in Vietnam Era Veterans.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2022
Accession Number
AD1194711

Entities

People

  • Benjamin L. Woolbright
  • John A. Iii Taylor

Organizations

  • University of Kansas Medical Center

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Acquisition
  • Agent Orange
  • Arsenicals
  • Biomedical Research
  • Bladder Cancer
  • Cancer
  • Cell Line
  • Cells
  • Culture Techniques
  • Data Analysis
  • Defoliants
  • Department Of Defense
  • Epithelium
  • Gene Expression
  • Medical Personnel
  • Metabolism
  • Methylation
  • Neoplasms
  • Rna Sequence Analysis
  • Tissues
  • Universities

Readers

  • Oncology
  • Toxicology/Environmental Toxicology