Defining and Modulating BRCAness to Improve the Precision of Prostate Cancer Therapy

Abstract

This proposal is focused on exploiting a specific subtype of metastatic CRPC, termed Homology Directed DNA Repair Deficient (HDR-D) prostate cancer (PC) to enhance treatment outcomes, reduce morbidity and improve survival. HDR-D represents at least 20% of metastatic PC and is most commonly identified through the genomic analysis of biopsies from metastatic tumors and identifying mutations in BRCA1, BRCA2 and related genes.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2022
Accession Number
AD1194712

Entities

People

  • Peter S Nelson

Organizations

  • Fred Hutchinson Cancer Center

Tags

DTIC Thesaurus Topics

  • Accuracy
  • Acquisition
  • Androgen Receptors
  • Biospecimens
  • Body Weight
  • Cancer
  • Carcinoma
  • Cell Line
  • Cell Physiological Processes
  • Data Management
  • Data Science
  • Detection
  • Diseases
  • Drug Combinations
  • Genetics
  • Health Services
  • Information Science
  • Medical Personnel
  • Neoplasms
  • Organizational Structure
  • Personnel Management
  • Statistics
  • Therapy
  • Tissues
  • Whole Genome Sequencing

Readers

  • Molecular and genetic basis of cancer.
  • Oncology
  • Prostate Cancer Biology.

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech