Clarifying the Role Played by Microglia and Astrocyte Activation in Veterans with Gulf War Illness Using Positron Emission Tomography (PET)
Abstract
The study objective is to assess whether veterans with GWI will show evidence of a chronic inflammatory process as measured by increased levels of astrocyte and microglial activation. We will determine the regionally specific pattern of astrocyte activation in 20 GW veterans. We will determine if there is regionally independence of the astrocyte activation from microglial activation and we will assess the utility of using FDG PET as a marker for activated astrocytes. We have now obtained all appropriate IRB approvals. This study will take place a Mass General Brigham Hospital and Boston University School of Medicine. We have a subcontract in place between these institutions for this study. We have contacted ten participants from the BBRAIN study to gage their interest in this call-back study. One has expressed interest in participating and we are working on getting this individual consented. We will be continuing to contact BBRAINS study participants to gage their interest and will be collecting data from them once they are consented.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2022
- Accession Number
- AD1194715
Entities
People
- Ronald Killiany
Organizations
- Boston University Medical Campus