Longitudinal, Objective Measurement and Analysis of Sleep-Wake Patterns in NF1 Patients
Abstract
Studies in NF1 knockout model organisms (mice and fruit flies) suggest that sleep disruption in NF1 may reflect a fundamental role for the neurofibromin protein (encoded by the NF1 gene) in the functioning of the molecular clock which serves to coordinate our internal time (body clock) with the external rhythm (day/night cycle). To date, there have been no true scientific measurements of timing, quantity and quality of sleep in NF1patients, with previous studies relying upon questionnaires to collect data. This study will address how prevalent sleep disruption is among people with NF1 and define the specific aspects of sleep that are affected. Sleep characteristics will be assessed in a large number (greater than 100) individuals with NF1 and healthy control (greater than 100) subjects, with 18 subjects recruited. This study will be the first to use objective data gathering methods to study sleep in NF1 patients.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2022
- Accession Number
- AD1194719
Entities
People
- Richa Saxena
Organizations
- Massachusetts General Hospital