Antibiotic Induced Dysbiosis Promotes Lung Metastasis
Abstract
Recent studies by various groups have revealed that antibiotics (ABX)-induced dysbiosis has systemic consequences including changes in vasculature beds at distal sites, and ultimately acceleration of lung carcinogenesis. These observations and their clinical implications motivated us to investigate whether dysbiosis also has an influence on lung metastasis. The long-term goal of our work is to define the systemic effects of ABX induced dysbiosis, to develop strategies to quell metastasis. The overall objective of this proposal is to determine the influence of ABX on lung metastasis progression and dissemination. Attaining this objective will be a major step in understanding the processes of lung metastasis and off-target effects of ABX. In this concept award, we test our central hypothesis is that ABX-induced dysbiosis increases fibronectin in the perivasculature stroma, creating a favorable pre-metastatic niche. None of the tasks of the original approved Statement of Work (SOW) were changed.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2022
- Accession Number
- AD1194722
Entities
People
- Ruud P. Dings
Organizations
- University of Arkansas at Little Rock