Delivery of Multifunctional Nanoparticles to the Brain

Abstract

Major Goals: Aim 1. To validate and improve the application of selected known brain-targeting molecules to nanoparticle CNS delivery, using the Q? virus-like particle as the proof-of-concept platform. Aim 2. To assess the immunogenicity, toxicity, and effects on BBB integrity of selected optimized nanoparticles from Aim 1 (and later Aim 3). Only those particles and formulations that result in no damage to the BBB (or transient disruption of the BBB that do not allow access of harmful agents) will be considered for further study and optimization. Aim 3. To discover nanoparticle motifs with generalized brain-targeting function by a biopanning strategy involving multiple phage display platforms in vivo.

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Document Details

Document Type
Technical Report
Publication Date
Mar 04, 2022
Accession Number
AD1195059

Entities

People

  • M. G. Finn

Organizations

  • Georgia Tech Research Corporation

Tags

DTIC Thesaurus Topics

  • Antibodies
  • Bacteriophages
  • Biochemistry
  • Blood
  • Blood-Brain Barrier
  • Brain
  • Cells
  • Chemical Compounds
  • Chemical Synthesis
  • Chemistry
  • Cultured Cells
  • Immunogenicity
  • Leviviridae
  • Light Scattering
  • Medical Personnel
  • Molecules
  • Nanoparticles
  • Packaging
  • Particles
  • Polymer Chemistry
  • Production
  • Proteins
  • Targets
  • Viral Structures
  • Viruses

Fields of Study

  • Chemistry
  • Medicine

Readers

  • Molecular Genetics
  • Nanocomposite Materials Science
  • Neurotoxicology

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech