Prophylactic Antibiotic-Coated Nail to Prevent Infection: A Clinical Trial

Abstract

Open tibia fractures are severe and common injuries sustained by Wounded Warriors in combat. Osteomyelitis and deep infection are unfortunately common after severe open fractures. Rates of infection following high-energy open fractures range from 6-40%. Furthermore, the injury mechanisms associated with the military involving penetrating fragments contribute to a higher rate of infection as compared to the civilian sector, in which blunt trauma is more common. To date, the field of orthopaedic surgery has not experienced a significant reduction in infection rates, despite numerous studies of a variety of different treatment options. Therefore, any novel strategy to reduce infection warrants rigorous study. The goal of this study is to investigate a potential treatment for serious open tibia fractures which are likely to become infected.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2022
Accession Number
AD1195578

Entities

People

  • Joseph R. Hsu

Organizations

  • Atrium Health

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Biomedical Research
  • Bone Fractures
  • Clinical Trials
  • Costs
  • Department Of Defense
  • Diseases
  • Engineering
  • Governments
  • Health Services
  • Humanities
  • Infection
  • Institutional Review Board
  • Intervention
  • Local Governments
  • Medical Personnel
  • Patent Applications
  • Professional Development
  • Standards
  • Training
  • Wound Infections

Fields of Study

  • Medicine

Readers

  • Immunology and Pathology
  • Materials Science (Mechanical Engineering).
  • Trauma or Military Medicine