Combat Ready Exposure Device (CRED): Validation of a Portable Exposure Biomarker Device for Lead and Other Heavy Metal Exposures
Abstract
The objective of this research project is to validate a portable all-in-one tool that will produce valid, comparable results to currently available technology for measurement of multiple biomarkers specific to different time frames of exposure from heavy metals. The research for the project will be conducted over two years and consists of two phases, each with a specific aim. Specific aim 1 involves the development, calibration, and validation of the portable x-ray fluorescence prototype device for human measurement of heavy metal body burden in the laboratory based setting (Phase 1, Year 1); and specific aim 2 focuses on the validation of the device for in vivo lead and toenail heavy metal measurements and heavy metal measurements using blood from a single finger prick compared to gold standard methods in a cohort of Soldier participants (Phase 2, Year 2). Over Year 1, significant efforts have been made towards the fabrication, calibration, and validation of the prototype device. Preparation of the human subjects protocol is well underway.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2021
- Accession Number
- AD1195589
Entities
People
- Susan P. Proctor
Organizations
- Henry M. Jackson Foundation for the Advancement of Military Medicine