Chamber Tests with Human Subjects XX Hypersensitivity to H as Demonstrated by Patch Tests Before and After Chamber Exposure to H Vapor
Abstract
A series of sensitivity tests on men before and after exposure to H vapor is described in this report. Doses of 1, 1/2, 1/4 and 1/8 micrograms of H in mineral oil, worn as closed patches on the forearm for four hours, represented a satisfactory subvesicant level for determining altered sensitivity. The intensity of reaction to patch tests by variation directly proportional to the outside effective temperature at the time the patches were worn. In addition to erythema, edema and/or folliculitis were observed in only 2 of 230 men tested prior to exposure to H vapor. After exposure, 26 percent of 169 men manifested edema and/or folliculitis to patch tests. These men were arbitrarily considered "sensitized". This sensitized group also showed a more intense erythema for each dose and a lower threshold dose for perceptible erythema than the non-sensitized group. Cases of abnormal generalized skin reaction following exposure to H vapor in the man-chamber are discussed. Eight kodachrone prints, illustration pertinent features, are included.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 15, 1946
- Accession Number
- AD1196139
Entities
People
- B. N. Stolp
- H. W. Carhart
- J. C. Conner
- J. H. Heinen
- N. M. Clausen
- W. H. Taylor
Organizations
- United States Naval Research Laboratory