Targeting Cholesterol Metabolism in Platinum-Resistant Ovarian Cancer

Abstract

The purpose of the project is to analyze cholesterol content and uptake in platinum resistant ovarian cancer and clear cell carcinoma and target this pathway by using HDL nanoparticles. The hypothesis is that platinum resistant ovarian cancer cells and tumors harbor unique metabolic features which render them dependent on cholesterol uptake and high intracellular cholesterol, due to increased capacity to withstand oxidative stress, and are susceptible to ferroptosis.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2022
Accession Number
AD1196920

Entities

People

  • Daniela E. Matei

Organizations

  • Northwestern University

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemotherapy
  • Cholesterol
  • Data Analysis
  • Department Of Defense
  • Knocking
  • Lipids
  • Medical Personnel
  • Metabolism
  • Nanoparticles
  • Neoplasms
  • Ovarian Cancer
  • Oxidative Stress
  • Platinum
  • Students
  • Universities

Readers

  • Cellular and Molecular Pathways of Apoptosis.
  • Exercise and Sports Science.
  • Oncology (Cancer Research).

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech