Protection Against Skeletal Muscle Atrophy
Abstract
Skeletal muscle atrophy due to bed confinement or cast-immobilization represents a serious medical problem in the military as well as in the civilian population.The increased protein degradation and decreased protein synthesis during muscle immobilization is extremely debilitating. In order to restore proper function to the atrophied muscle, reloading is required. Muscle reloading unfortunately results in a significant amount of oxidative damage. Therefore, means to minimize muscle damage during this period of reloading would also be extremely advantageous for proper recovery. Our interest is to investigate how the heat shock proteins (hsp), a family of proteins present in all mammalian cells, is able to protect muscle tissue against muscle atrophy. The hsps are able to regulate protein homeostasis but also protect against oxidative stress, apoptosis and inflammation. We have demonstrated that the hind limb muscles of hsp70 overexpressing transgenic mice exhibit improved structural and functional recovery after a 7-day immobilization and 7-day recovery protocol as compared to control mice.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 2023
- Accession Number
- AD1196930
Entities
People
- Ruben Mestril
Organizations
- Loyola University New Orleans