Treatment of Traumatic Brain Injury (TBI) with Customized Polymer-Based Low Volume Resuscitation (LVR)
Abstract
T Traumatic brain injury (TBI) caused by blast or projectile injury results in brain swelling from vascular edema and later from intracellular metabolic cell swelling. This causes compression of the microcirculation and lowers tissue perfusion, oxygenation, and more cellular ischemia, which causes more metabolic swelling and microvascular compression in a self-amplifying cycle. We have developed new cell impermeant-based solutions to resuscitate shock patients by reversing this cycle and hypothesized it would work in TBI. Studies in rodents with contusion-induced TBI resulted in significant cell swelling, which was reversed by the use of polyethylene glycol (PEG) 20k based impermeant solutions given immediately after TBI. This was further associated with reductions in neuro-inflammation in the tissue as well as clear benefits to the longitudinal learning and cognitive behavior in the rats after recovery. Specifically, rodents receiving impermeant-based low volume resuscitation containing PEG-20k performed significantly better in the Morris Water Maze test that measures learning compared to controls receiving the same volume of carrier solution.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2022
- Accession Number
- AD1197729
Entities
People
- Martin J Mangino
Organizations
- Virginia Commonwealth University