Investigating the Expression, Role, and Targeting of Collagen Modifying Prolyl 4-Hydroxylase P4HA1 in Prostate Cancer Progression and Metastasis
Abstract
Prostate cancer (PCa) is the most common malignancy and the second most common cause of cancer mortality of men in the United States. Complex molecular and signaling events converge leading to PCa initiation, unregulated growth, invasion, and metastasis. There is a growing concern that PSA screening leads to over-diagnosis resulting in excessive treatment of indolent PCa without significant clinical benefit. Thus identification and validation of novel diagnostic and prognostic molecular biomarkers of PCa as well as the oncogenic therapeutic targets are of critical importance for the early detection, management, and cure of PCa. Our recent studies utilizing gene expression profiling and next generation sequencing of prostate cancer tissues identified prolyl hydroxylase P4HA1, a key enzyme in collagen modification resulting in extracellular matrix modification in cancer as upregulated in primary PCa and castration resistant PCa. Being an enzyme, P4HA1 is a viable therapeutic target amenable to small molecule inhibition.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2022
- Accession Number
- AD1199168
Entities
People
- Sooryanarayana Varambally
Organizations
- University of Alabama