The Impact of Childhood-Onset Lupus on the Developing Brain

Abstract

This research study seeks to understand how and why childhood-onset lupus affects the developing adolescent brain. The study will look for better ways to identify early cognitive changes, and the factors contributing to the changes. We will use advanced magnetic resonance imaging techniques to learn about brain structure and function in adolescents newly diagnosed with lupus. We will study these adolescents over time, and compare their brain development to that of healthy peers. The study aims to: compare brain structure, function and development between adolescents with lupus and healthy peers, using measures obtained by advanced MRI over time; examine relationship between the MRI findings and cognitive test performance, and; examine the relationship between the MRI findings and lupus-related factors, such as disease activity, prednisone exposure, and concurrent depression/anxiety and pain.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2022
Accession Number
AD1199169

Entities

People

  • Andrea Knight

Organizations

  • Hospital for Sick Children

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Adolescents
  • Biomedical Research
  • Brain Injuries
  • Data Analysis
  • Department Of Defense
  • Diseases
  • Health
  • Health Services
  • Hospitals
  • Imaging Techniques
  • Lupus
  • Magnetic Resonance
  • Magnetic Resonance Imaging
  • Medical Personnel
  • Neuroimaging
  • Public Health
  • Resonance
  • Security

Readers

  • Medical Imaging.
  • Neurological Diseases/Conditions/Disorders
  • Oncology