Genome-Wide Association Study in Acquired Aplastic Anemia

Abstract

Aplastic Anemia (AA) is a previously universally fatal disease characterized by a hypocellular bone marrow and pancytopenia. AA incidence is skewed across the globe, being 2-3fold higher in Asia than in Europe. In a variety of studies, chemical exposures and infections in different geographic areas have been described as risk factors for AA, butin consistently, based on small sample sizes, and at prevalence too low to account for large geographic differences. Genome wide association study GWAS is a powerful research method that compiles genetic variants from many individuals to investigate the association of common genetic markers with a disease phenotype. It has led to the discovery of important new genes and associations in a number of medical conditions.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2022
Accession Number
AD1199170

Entities

People

  • Neal Young

Organizations

  • Geneva Foundation

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Biomedical Research
  • Blood Transfusions
  • Bone Marrow
  • Department Of Defense
  • Diseases
  • Genetic Markers
  • Genetics
  • Genome
  • Geographic Regions
  • Health Services
  • Hematologic Diseases
  • Hematology
  • Information Operations
  • Institutional Review Board
  • Law
  • Local Governments
  • Maryland
  • Medical Personnel
  • Patent Applications
  • Professional Development
  • Risk Factors
  • South Korea
  • Students
  • United States
  • Universities

Readers

  • Infectious Disease/Epidemiology
  • Molecular and genetic basis of cancer.
  • Women's Health and Cancer Risk Research: African American Women and Pregnancy Outcomes.

Technology Areas

  • Biotechnology