Effects of Mild Traumatic Brain Injury on Retinal Ganglion Cell Light Adaptation
Abstract
Many people develop an intolerance to light after a head injury. We do not understand why this occurs and how it is linked to head injuries. It is our speculation that cells in the retina of the eye become unable to adjust appropriately to changes in environmental light levels, with the result being that they signal the brain that it is brighter than it actually is. In this work, we will study individuals who had a recent brain injury and developed light intolerance, individuals with a recent brain injury who do not experience light intolerance, and a comparison group of people who have never had a brain injury. We will measure the function of certain retinal cells by recording their electrical activity, which can be detected with a probe placed near the eyelid, when the eye is stimulated with light. We will also measure the function of a different group of cells in the retina by measuring how the pupil changes size in response to different light exposures. These techniques could provide new approaches for clinicians to use, allowing them to quantify the magnitude of the light intolerance experienced by these patients.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2022
- Accession Number
- AD1199171
Entities
People
- Andrew Hartwick
Organizations
- Ohio State University