Muscarinic 3 Receptor in Pancreatitis Pathogenesis and Therapy
Abstract
The proposed research project addresses the topic area of pancreatitis. The main goal will be to determine whether hyper-activation of the M3 acetylcholine receptor located on pancreatic acinar cells induces pancreatitis. We will study this through premature intra-acinar cell trypsinogen activation and measuring increased pro-inflammatory NF-kB pathway signaling as well as by targeting the muscarinic 3 receptor with an FDA approved chemical antagonist Darifenacin. Additionally, we will also study commercially available human pancreatic acinar cells to see if they respond similarly to our mouse studies.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2022
- Accession Number
- AD1199172
Entities
People
- Baoan Ji
Organizations
- Mayo Clinic