Host-Based and Pathogen-Based Proteomic Biosignatures for the Diagnosis of Lyme Disease in Children
Abstract
We propose to identify a novel blood-based biomarker signature to distinguish between patients with Lyme disease and patients with symptoms compatible with Lyme disease but who ultimately were found to have alternate diagnoses, i.e. patients with symptoms mimicking Lyme disease. In pilot studies, we have shown differential abundances of a subset of blood proteins which alone or in combination show promise as a sensitive diagnostic that could be used to improve on currently available diagnostics for early Lyme disease. We hypothesize that a novel blood-based biomarker (or set thereof) has the potential to improve diagnostic accuracy for patients with suspected Lyme disease.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2022
- Accession Number
- AD1199176
Entities
People
- Hanno Steen
- Lise E Nigrovic
Organizations
- Boston Children's Hospital