Long-Term Impact of Military-Relevant Brain Injury Consortium (LIMBIC) Award

Abstract

The Long-Term Impact of Military-Relevant Brain Injury Consortium (LIMBIC) is a coordinated, multicenter, nationwide translational research collaboration that is studying the effects of mild, combat-related TBIs, whether single or repeated, on chronic disabling symptoms, recovery from combat and trauma-related comorbidities, and long-term brain function. This Consortium builds upon the accrued experience of the previous Chronic Effects of Neurotrauma Consortium (CENC) funding cycle (2013-2019), where an Executive Leadership team, a Study Coordinating Center, centralized research Cores (Database and Biostatistics, Imaging, Biomarker), Scientific and Community Advisory Boards, a large, nationwide, multi-level, Prospective Longitudinal Study (PLS) and a multi-site, Retrospective Database Study (RDS) were all established and implemented. These essential elements of CENC have been carried over to LIMBIC and key enhancements of the PLS and RDS have been implemented. The LIMBIC team has completed all regulatory activities, personnel hiring, technical upgrades and documentation adjustments needed for the PLS to initiate follow-up evaluations on all extant participants and also recommence new recruitment of participants, with the easing of COVID-19 research restrictions. The LIMBIC PLS will specifically; 1) expand the current, well-characterized participant cohort with a history of deployment and combat exposure from 1,500 individuals exclusively from the OEF-OIF conflicts to 3,000 participants from all combat-eras to allow for greater statistical opportunities and flexibility in evaluating outcomes in both cross sectional and longitudinal studies, 2) expand recruitment and testing of active duty and Veteran service members from 2 military/7 Veteran sites to 8 military/9 Veteran sites to increase recruitment of active duty service members, 3) refine existing and add new outcome measures to better evaluate the long-term effects of the number and types of blasts exposures.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2022
Accession Number
AD1199278

Entities

People

  • David X. Cifu

Organizations

  • Virginia Commonwealth University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Air Force
  • Brain
  • Brain Injuries
  • Data Analysis
  • Data Mining
  • Dementia
  • Employment
  • Health Services
  • Information Science
  • Machine Learning
  • Medical Personnel
  • Military Medicine
  • Pain
  • Sleep Disorders
  • Statistical Analysis
  • Traumatic Stress Disorder
  • United States

Fields of Study

  • Medicine

Readers

  • Auditory Neuroscience/Auditory Physiology.
  • Clinical Trial Research.
  • Traumatic Brain Injury (TBI) and Cognitive Aging in the Guam and Border Populations Affected by Alzheimer's Disease and Tau-Associated Dementias.