Effects of Thyroid Hormone Metabolite Treatment for Postmenopausal Heart Repair
Abstract
During menopause circulating sex hormones decline as well as thyroid function. Estrogen reduction is correlated with reduced protection from cardiovascular diseases. Studies in pre-menopausal women show that hysterectomy, is associated with higher risk of cardiovascular disease. Similarly, a loss of thyroid hormone (TH) is also associated with reduced cardiac health in women. Research is needed to further understand the relationship between the loss of estrogen and thyroid hormone and cardiovascular disease. We hypothesize that TH (T3, 3,3'-T2) treatment will increase expression of GPR30 and reduce infarct area and fibrosis post-myocardial infarction (post-MI) in ovariectomized (OVX) female rats and that 3,3'-T2 will preferentially activate thyroid hormone receptor alpha proving more efficacious than T3 for heart repair. To test our hypothesis, we will 1) evaluate the role of THs (T3, 3,3'-T2) post-MI using euthyroid and hypothyroid female rats and compare efficacy of salvage treatment and 2) evaluate the role of THs (T3, 3,3'-T2) post-MI in OVX female rats with and without estrogen (E2) replacement therapy and compare efficacy of treatment. Major findings include that induction of hypothyroidism was found to decrease pulse rate (indicative of bradycardia) and result in symptoms similar to heart failure (reduced ejection fraction and fractional shortening).
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 2022
- Accession Number
- AD1199706
Entities
People
- Carly S Filgueira
Organizations
- Houston Methodist Research Institute