Decoding the Mechanoregulation of Breast Tumor Organoid Invasion, One Cell at a Time
Abstract
The vast majority of breast cancer deaths are related to metastasis, during which cell migrate and invade surrounding tissue. Attempts to design effective drug treatments for metastasis have largely failed. A major reason for this failure is the plasticity of migrating cancer cells: they are able to rapidly switch between different modes of migration when faced with different extracellular environment. As a consequence, drugs that target a single migration mode will not be effective in stopping metastasis. This plasticity is poorly understood but depends strongly on the mechanical properties of the extracellular matrix (rigidity, fiber alignment, pore size, etc.). In this project, we will carry out quantitative experiments which determine the modes of migration as a function of the extracellular matrix properties, quantify the transitions between migration modes, and determine how there modeling of the extracellular matrix couples back to the migration mode and mode transitions.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2022
- Accession Number
- AD1199719
Entities
People
- Wouter-Jan Rappel
Organizations
- University of California Regents