A Novel Advanced Resuscitation Fluid for Traumatic Brain Injury with Hemorrhagic Shock
Abstract
Traumatic brain injury (TBI) is frequently accompanied by hemorrhagic shock (HS) which significantly worsens neurologic outcome, and increases mortality. Current resuscitation fluids (RF) for volume expansion after TBI with HS do not adequately ameliorate impaired microvascular cerebral blood flow (mvCBF). We suggested the addition of drag reducing polymers (DRP) to resuscitation fluid (DR-RF) for TBI with HS which will reduce the severity of brain injury, increase survival rate, improve neurologic recovery and will reduce the volume of resuscitation fluid required to prevent the transition to an irreversible stage and death or functional impairment of the brain. The purpose for the proposed research is to apply DRP as an additive to resuscitation fluids after TBI with HS, to determine which mechanisms are affected by DRP in the acute and late recovery phases and to define most effective parameters for application. During reported period we showed that colloid, hypertonic and colloid-based DRP-RF significantly improves cerebral regional and microvascular circulation and tissue oxygenation impaired by TBI/HS. Effect lasts at least 6 hours. Colloid-based DRP-RF was more effective than crystalloid and hypertonic-based DRP-RF tested. We have also done evaluation of TBI/HS-induced metabolic stress of mitochondria, hypoxia, neuronal survival and microthrombosis and beneficial effects of DRP-RF-vs. RF. Sub-Contractor performed experiments on DRP characterization and storage and drag reduction test circuit development. The results were presented on 4 conferences, one manuscript published, one accepted and two are in preparation.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2023
- Accession Number
- AD1199723
Entities
People
- Afshin Divani
Organizations
- University of New Mexico