Intranasal DMTS for Acute Cyanide Poisoning
Abstract
The US chemical defense program has identified finding a non-intravenous, safe antidote for acute cyanide toxicity a high priority. Current antidotes require intravenous infusion making their utility in a mass casualty poisoning limited. Evidence shows intranasal administration of medications in the prehospital setting is a safe, effective, and convenient route compared to traditional routes of drug delivery. Dimethyl trisulfide has been shown to be an effective antidote when administered via intranasal administration in a rodent model of cyanide poising. We have demonstrated that DMTS can be successfully administered via the intranasal route in swine resulting in systemic absorption of DMTS. We have also demonstrated intranasal administration of DMTS rescues from lethal cyanide poisoning.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2022
- Accession Number
- AD1200782
Entities
People
- Tara Hendry-hofer
- Vikhyat S Bebarta
Organizations
- University of Colorado Denver