Exploring the Commercialization of a Smart Antifungal Wound Therapy

Abstract

We have developed an antifungal hydrogel product that provides a fungi-triggered release of encapsulated antifungal therapeutics. This controlled release technology can eradicate fungal infections before the development of an invasive infection, all while limiting exposure to antifungal therapeutics. The hydrogel is fabricated using a polymer-peptide backbone that degrades in the presence of fungal enzymes. Encapsulated therapeutics are only released when the hydrogel is degraded by these fungal enzymes. Our previous Department of Defense funded work has thoroughly characterized the in vitro and ex vivo release behavior and antifungal efficacy of this product. We are currently examining the in vivo antifungal activity in a fungal wound infection model and exploring properties including storage stability.

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Document Details

Document Type
Technical Report
Publication Date
Dec 31, 2021
Accession Number
AD1200876

Entities

People

  • Anita Shukla
  • Carol Malysz
  • Noel L Vera-gonzalez

Organizations

  • Brown University

Tags

DTIC Thesaurus Topics

  • Antifungal Agents
  • Bandages
  • Biomedical Engineering
  • Chemical Engineering
  • Commerce
  • Department Of Defense
  • Economic Development
  • Engineering
  • Foot Diseases
  • Fungi
  • Health Services
  • Infection
  • Medical Personnel
  • Standards
  • Therapy
  • Wound Infections
  • Wounds And Injuries

Fields of Study

  • Biology

Readers

  • Nanoscale Plasmonic Nanotechnology
  • Oncology (Cancer Research).
  • Vector-Borne Disease and Entomology