Optimization of Repeat Dosing with Intramuscular Dimethyltrisulfide Following Acute Cyanide Poisoning

Abstract

The US chemical defense program has identified finding a non-intravenous, safe antidote for acute cyanide toxicity a high priority. Current antidotes require intravenous infusion making their utility in a mass casualty poisoning limited. Dimethyl trisulfide has been shown to be an effective antidote when administered via intramuscular injection in rodent and swine models of cyanide poisoning. However, efficacy following repeat dosing based on clinical indicators has not been evaluated. We have demonstrated that repeat dosing of DMTS rescues from highly lethal cyanide poisoning. These studies are important since certain cyanide exposures may result in ongoing toxicity over extended periods of time, requiring additional antidote administration.

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Document Details

Document Type
Technical Report
Publication Date
Aug 31, 2022
Accession Number
AD1201010

Entities

People

  • Tara Hendry-hofer
  • Vikhyat S Bebarta

Organizations

  • University of Colorado Boulder

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Antidotes
  • Biomedical Research
  • Blood Pressure
  • Casualties
  • Colorado
  • Computer Vision
  • Department Of Defense
  • Electronic Mail
  • Governments
  • Humanities
  • Information Operations
  • Infusions
  • Inventions
  • Local Governments
  • Maryland
  • Medical Personnel
  • Object Recognition
  • Optimization
  • Patent Applications
  • Poisoning
  • Professional Development
  • Security
  • Standards
  • Technology Transfer
  • Training

Fields of Study

  • Medicine

Readers

  • Molecular Genetics
  • Toxicology/Environmental Toxicology