Extracellular Vesicles as Potential Drivers of Myelin Health and Myelin Repair in Pregnant MS Patients

Abstract

This research study explores whether Extracellular Vesicles (EVs) that are produced during pregnancy may have beneficial roles in Multiple Sclerosis, in particular, to myelin health and/or repair capacity. We have characterized EVs from both pregnant and control mice, have completed studies to determine the effect of pregnancy EVs on oligodendrocyte progenitor cell proliferation, differentiation, and myelin gene expression. In addition we have sequenced miRNA cargos contained within pregnancy EVs compared to non-pregnant control EVs. We are currently working to establish the cellular and temporal requirements for EV uptake in the brain, as well as for the capacity of pregnancy EVs to alter myelin repair trajectories using both cuprizone-mediated demyelination in the brain, and lysolecithin-mediated demyelination in cerebellar slice cultures.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2022
Accession Number
AD1201247

Entities

People

  • Holly Colognato

Organizations

  • State University of New York

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Acquisition
  • Alzheimer Disease
  • Biomedical Research
  • Brain
  • Cells
  • Culture Techniques
  • Detection
  • Diseases
  • Dynamics
  • Environment
  • Extracellular Vesicles
  • Maryland
  • Maturation
  • Medical Personnel
  • Multiple Sclerosis
  • Neurodegeneration
  • Pregnancy
  • Professional Development
  • Sclerosis
  • Students
  • Technology Transfer

Fields of Study

  • Medicine

Readers

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