Tiered In Vitro Toxicity Testing WP19-1338 Novel Additive Manufacturing Propellants
Abstract
The compounds ABID ([3-[5-(prop-2-enoyloxymethyl)isoxazol-3-yl]isoxazol-5-yl]methyl prop-2-enoate), n,n-bis(2-propyl) polyoxypropylenediamine (Jeffamine registered SD 2001 or SD2001) and glyceryl poly(oxypropylene)triamine (Jeffamine T5000 or T5000) are being assessed as components in potential new binder systems to replace isocyanate-based binders in energetic formulations. This study evaluated the toxicity of T5000, SD2001, and ABID in several in vitro test systems, including the Ames mutagenicity assay, the Microtox Acute Toxicity Test and skin sensitization. Data from the h-CLAT assay were also used to predict an acute oral toxicity hazard category. T5000, SD2001, and ABID were not mutagenic in Ames, ABID was predicted to be highly toxic (GHS category 1) to aquatic organisms and SD2001 and ABID were skin sensitizers. Data from this study are used to assist in making environment and health-based decisions regarding the design and selection of formulas and materials for further development of new munition compounds.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 31, 2022
- Accession Number
- AD1201479
Entities
People
- Jorge Ruiz
- Valerie H. Adams
Organizations
- United States Army Center for Health Promotion and Preventive Medicine