A Time-Dependent Physiological Model of Healing for a Stable, Closed Bone Fracture

Abstract

A time-dependent physiological model governed by seven ordinary differential equations for the healing of closed, stable fractures ispresented. This model characterizes local inflammation and repair dynamics of the fracture site and surrounding area following injury.Numerical simulations will demonstrate the ability of the model to produce biologically sound results and to discuss model dynamics in the case of normal fracture healing.

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Document Details

Document Type
Technical Report
Publication Date
May 21, 2023
Accession Number
AD1201579

Entities

People

  • Angela Reynolds
  • Christina Wagner
  • Michelle Craft
  • Rachel Jennings

Organizations

  • Applied Research Associates (United States)

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Adaptive Immunity
  • Blast Injuries
  • Blood
  • Bone And Bones
  • Bone Diseases
  • Bone Fractures
  • Bone Regeneration
  • Burns
  • Cells
  • Granulocytes
  • Hemorrhage
  • Lymphocytes
  • Macrophages
  • Medical Personnel
  • Osteoblasts
  • Osteogenesis
  • Osteoporosis
  • Phagocytes
  • T Lymphocytes

Fields of Study

  • Biology

Readers

  • Calculus or Mathematical Analysis
  • Materials Science (Mechanical Engineering).
  • Wave Propagation and Nonlinear Chaotic Dynamics.