Mechanisms and Consequences of Hedgehog Signaling and Immune Infiltration in Schwannoma
Abstract
Schwannomas are common tumors of the peripheral nervous system that arise from Schwann cells. Although schwannomas have excellent outcomes after resection or radiosurgery1-4, over 75% of patients develop permanent and debilitating pain from nerve injury or cytokine activation of nociceptors in the tumor microenvironment. Existing treatments of surgery and radiotherapy rarely improve cancer-associated pain from schwannomas and often exacerbate neuropathic conditions. Although radiotherapy-induced peripheral neuropathy is rare, complications after surgery for schwannomas is common. Indeed, between 30% and 90%of schwannoma patients develop postoperative complications, most commonly in the form of new or worse sensory deficits or pain. Thus, there is an urgent and unmet need for new strategies to treat schwannomas patients.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2022
- Accession Number
- AD1201606
Entities
People
- David Raleigh
Organizations
- University of California Regents