Attenuation of Anorexia-Like Phenotype Through Obese Adipose Tissue Transplant
Abstract
The present grant was based on our preliminary data showing that 1) adipose tissue is the primary location of 'metabolic memory' of earlier nutrition status in previously obese animals, and 2) an obese adipose tissue transplant extends survival and reduces the voluntary wheel running of recipient mice in the activity based anorexia (ABA) paradigm, an animal model of aspects of anorexia nervosa. During the first year, we found that obese fat transplant increases survival during ABA by reducing wheel running, rather than by altering food intake or metabolism. AgRP neurons have been reported to regulate wheel running and mobilize fuel during ABA. Therefore, it will be very interesting to embark on our experiments proposed in year 2, which are to 1) lesion and 2) record the activity of AgRP neurons in mice receiving either control or obese fat transplants during ABA. In summary, our work is uncovering the mechanisms which underlie the ability of obese fat transplant to reduce anorexia-related behavior and weight loss, which could lead to novel treatments for anorexia nervosa and related disorders.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 2023
- Accession Number
- AD1202711
Entities
People
- Stephanie Dulawa
Organizations
- University of California, San Diego