The Prevalence of Alzheimer's Disease Pathology After Traumatic Brain Injury in Veterans and Civilians: A Biomarker Study of Beta-Amyloid and Tau
Abstract
Background: Retrospective studies suggest that traumatic brain injury (TBI) increases the risk of Alzheimer's disease (AD) four-fold. This has not been supported by recent PET imaging studies including our previous work (Dore V, Cummins TL, et al. Tau, beta-amyloid, and glucose metabolism following service-related Traumatic Brain Injury in Vietnam war veterans: The AIBL-VETS study. PREPRINT. https://www.medrxiv.org/content/10.1101/2022.03.10.22272230v1). PET scanning to measure the proteins Amyloid and Tau are the key predictors of future AD. This study investigates civilians and veterans with single TBI using the latest generation of more sensitive imaging biomarkers. Hypothesis: That individuals with traumatic brain injury (TBI) have a higher prevalence of AD related pathology and neurodegeneration compared to age matched controls. Study Design: We will use the latest generation of PET imaging and 7 Tesla MRI to measure AD pathology and chronic traumatic brain damage. We will study 150 elderly TBI subjects and 100 age-matched controls. In addition, psychological testing will be carried out such that the imaging results can be tested for correlation with clinical endpoints.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2022
- Accession Number
- AD1203246
Entities
People
- Christopher C Rowe
Organizations
- University of Melbourne