Elevated Uracil Glycosylase Coupled to Reduced Base Excision Repair Promotes AA PCa Progression
Abstract
African American (AA) males have a higher incidence of PCa, are more likely to be diagnosed at a younger age, and often present with more advanced and aggressive disease. While there are risk factors associated with the development of AA PCa, we lack detailed mechanisms about the unique tumor biology in AA PCa, which contributes to the disparity in outcomes from these patients. We have established a cross-disciplinary research team containing experts in DNA damage, PCa and health disparities, PCa clinical management and prostate pathology to address the Prostate Cancer Research Programs overarching challenges to define the biology of lethal prostate cancer to reduce death and to develop treatments that improve outcomes for men with lethal prostate cancer with the long-term goal of reducing the disparity in survival outcomes for AA PCa patients.We are leveraging clinical data from AA and EA tumors to develop improved cell line models that recapitulate metabolic and DNA repair differences seen in patient samples. We will use these models to dissect biological features unique to AA tumors that may allow targeted therapeutic intervention in the near future. The mechanistic data generated by this proposal will support the targeted use of PARP inhibitors for AA PCa patients that show dysregulated BER from metabolic reprogramming.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2023
- Accession Number
- AD1203271
Entities
People
- Natalie Gassman
Organizations
- University of Alabama