Impact of Analgesics on Cardiovascular and Respiratory Responses After Trauma and Hemorrhage
Abstract
Blood loss is the leading cause of death on the battlefield, and it is important that pain medications used on the battlefield notinterfere with the bodys natural responses during bleeding that protect against death. The proposed studies will evaluatealternatives to existing pain medications to identify better options for battlefield pain management of the bleeding, injuredService Member. During the first year, the following were completed:--Major Task 1, Subtask 1: The animal protocol for Specific Aim 1 received IACUC and ACURO approval.--Major Task 1, Subtask 2: The estimate blood volume in a rat will be 6.84 .67 ml/100 g body weight.--Major Task 1, Subtask 3: The doses of ketamine (50mg/kg) and midazolam (5mg/kg) were determined for use in the study.The following were initiated, and studies are ongoing:--Major Task 1, Subtask 4: Effects of ketamine sedation with/without midazolam on compensatory responses after hemorrhage--Major Task 2, Subtask 1: Effects of ketamine sedation with/without midazolam on survival rate after decompensatedhemorrhage with 55% blood volume loss
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 2023
- Accession Number
- AD1203273
Entities
People
- Carmen Hinojosa-Laborde
Organizations
- United States Army Institute of Surgical Research