Non-Uniformly Sampled MR Correlated Spectroscopic Imaging in Breast Cancer and Nonlinear Reconstruction
Abstract
Purpose: i) Non-uniform sampling (NUS) schemes will be combined with 5D EP-COSI sequence. ii) GS based CS reconstruction schemes will be developed for accelerated acquisition and optimized to reconstruct the NUS EPCOSI data with better reliability . iii) Alterations in metabolite and lipid levels will be correlated with ADC changes in breast cancer patients compared to healthy women which will improve the diagnostic accuracy. The study patient cohort will include 50 patients with malignant breast carcinoma, 20 patients with benign breast tumor and 20 healthy women. Scope: To demonstrate improved MR spectroscopic imaging techniques will enable unambiguous measurement of metabolites and lipids in situ, which could potentially complement the existing diagnostic modalities commonly used in breast carcinoma. Also, monitoring glycine, taurine and myo-inositol may play a role in breast cancer therapeutic validations. Major finding: Successful Implementation of a novel 5D EP-COSI, novel reconstruction using GS and its correlation with DWIMRI for evaluation in 32 malignant and 17 benign breast cancer patients, and 19 healthy women, using a 3T MRI scanner. The5D EP-COSI data showed novel metabolite changes in addition to water, and DWI images showed reduced ADC values in suspicious lesions of breast cancer patients compared to healthy women. Novel biomarker detection of glycine, myo-inositol invivo was achieved using 5D EP-COSI. Further acceleration may enable shorter acquisition in 15 minutes or so.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2022
- Accession Number
- AD1203288
Entities
People
- Michael A Thomas
Organizations
- University of California, Los Angeles