Optimal Dynamic Control of Multiple Quantum Systems for Multiplexed Bio-Network Analysis and Optogenetics
Abstract
All modern high technology machines, from aircraft out to self-driving cars, contain large numbers of(i.e., multiplexed) switches and sensors to assure high performance or alter the machines function as desired. Similarly, an emerging high priority goal in biology is to create what may be called two-way optical communications and control with living systems, enabled by a multiplexed biological switching and sensing capability. Here, switching refers to the turning off or on of particular biological pathways or processes, and sensing refers to detection of the resultant action of the switching events. Great progress is being made using genetic engineering to create multiple classes of switches and sensor molecules, often consisting of proteins with an embedded chromophore. Typically, the chromophore undergoes an optically induced structural transformation, corresponding to either a switching event in the case of so-called optogenetics or, concomitantly, in the case of sensor molecules, the creation of a state that may be detected (e.g., by fluorescence). The recent growing family of optogenetic switches or sensor proteins addresses only half of the switching/sensing objective, as it is necessary to employ appropriate optical sources to utilize these molecules for their designed purposes. Up until the inception of the present research project, the operation of molecular switches and the observation of subsequent sensing was performed in the linear optical regime, thereby greatly limiting the number of switches and sensors which may simultaneously function in complex biological environments.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 28, 2021
- Accession Number
- AD1203610
Entities
People
- Herschel A. Rabitz
Organizations
- Princeton University