Optimization of an Acute Care Strategy to Stabilize Composite Tissue Injuries and Facilitate Improved Functional Outcomes for Accelerated Return to Duty
Abstract
This current study seeks to address tissue regeneration in musculoskeletal disorders by suggesting a new staged paradigm for open extremity fractures. This staged treatment consists of the initial surgical placement of a muscle void filler within a volumetric muscle loss defect during the bone reconstruction process to mitigate the well accepted deleterious endogenous wound healing response to muscle injury, namely extensive fibrosis of the wound bed and irreversible alterations in muscle architecture. The goal is to provide a tissue specific, pro-myogenic environment for acceptance and integration of a second staged regenerative medicine therapies for both the bone fracture and muscle. In this project, we will be testing how muscle void fillers improve muscle function and bone healing in a porcine model of composite tissue injury (CTI). This work is collaborative between the swine surgeons and the muscle researchers at Uniformed Services University. The initial specific aims, specifically developing the void filler are near completion at USUHS. We are now ready to move into porcine testing. We will use our porcine CTI model to test our hypotheses.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2022
- Accession Number
- AD1203729
Entities
People
- Todd O McKinley
Organizations
- Indiana University