Developing Novel Strategies to Uncouple Immunotherapy-Induced Autoimmunity from Antitumor Immunity
Abstract
The project aims to study underlying mechanisms of cancer immunotherapy driven adverse events. These adverse events affect tissue and organs similar to autoimmune disease, and is T cell driven. As human organ biopsies are challenging to collect, we propose studying organ infiltrating T cells in animals treated with immunotherapy. By comparing organ and tumour infiltrating T cells, we aim to identify druggable targets that can be targeted to manage these adverse events without affecting the anti-tumour immune response. We report that gene expression of T cells from affected organs and tumours are very different, suggesting that there are targets that we could potentially focus on. We successfully performed flow cytometry and bulk RNA sequencing on T cells, and are in the process of completing single cell sequencing and analysis.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2023
- Accession Number
- AD1205010
Entities
People
- Jonathan Chee
Organizations
- University of Western Australia