In Vivo Engineering of the Heart
Abstract
Cardiomyopathy (heart muscle disease) is a leading cause of heart failure, and congenital heart disease often leads to heart failure in adults. Heart transplantation remains the gold standard for treating patients with advanced heart failure, and many people desperately need a donor heart. For this reason, there are ongoing trials to create artificial hearts with tissue engineering approaches. However, a number of challenges remain to be overcome due to the complexity of the real heart. This proposal aims to overcome the complexity by utilizing the machinery present in a developing organism with cells that serve as building blocks to make the heart during fetal development. The successful demonstration of generating such hearts will provide unprecedented insights into generating transplantable hearts from patients own cells.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2023
- Accession Number
- AD1205233
Entities
People
- Chulan Kwon
Organizations
- Johns Hopkins University