Prothrombin Complex Concentrate for Prolonged Field Care of War Casualties
Abstract
Patients who initially survive from traumatic thoracic injury are at risk for Acute Respiratory Distress Syndrome (ARDS). The only proven treatments available once ARDS has developed are low tidal volume ventilation (ARDSnet) and proning, but there is no existing treatment strategy to prevent the onset of ARDS following traumatic injury. As a potential solution, recent evidence suggest that prothrombin complex concentrate (Kcentra) acts similarly to plasma to prevent vascular leak and edema, but this has not been investigated in the trauma setting. Therefore, the purpose of this project is to conduct a series of in vitro and in vivo studies to determine if the therapeutic administration of Kcentra prevents the development of ARDS following pulmonary contusion and hemorrhagic shock.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2023
- Accession Number
- AD1205952
Entities
People
- Martin A. Schreiber
Organizations
- Oregon Health & Science University