Tesamorelin Therapy to Enhance Axonal Regeneration, Minimize Muscle Atrophy, and Improve Functional Outcomes Following Peripheral Nerve Injury and Repair

Abstract

This study is a randomized, double-blinded, placebo-controlled clinical trial with the primary aim of assessing the efficacy of tesamorelin for peripheral nerve injuries. Patients with ulnar nerve lacerations at the wrist, repaired in a primary fashion, will be eligible for enrollment. Subject follow up and outcome measurements will take place at Johns Hopkin Hospital. We plan to enroll 36 subjects over 4 years. At the end of the study, if tesamorelinis found to be efficacious, limited off-label use may be justified. Theratechnologies will then pursue a larger Phase 3 clinical trial.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2023
Accession Number
AD1206364

Entities

People

  • Ala Elhelali
  • Sami Tuffaha

Organizations

  • Johns Hopkins University

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Clinical Trials
  • Data Analysis
  • Electronic Mail
  • Health Services
  • Hospitals
  • Management Personnel
  • Maryland
  • Medical Personnel
  • Organizational Structure
  • Patent Applications
  • Peripheral Nervous System
  • Pituitary And Hypothalamic Hormones And Analogues
  • Professional Development
  • Technology Transfer
  • Test Methods
  • Therapy
  • Ulnar Nerve
  • Universities

Fields of Study

  • Medicine

Readers

  • Clinical Trial Research.
  • Neuroscience
  • Neurotrauma and Rehabilitation Medicine.