Noncanonical Function of STING in ccRCC
Abstract
ccRCC (clear cell renal cell carcinoma) accounts for the majority of kidney cancer, where inactivation of a gene called VHL and hyperactivation of another gene called PI3K are frequently observed. However, therapies targeting these signaling pathway showed limited clinical benefits. Thus, new treatment regimens are urgently needed. Aiming to identify new drug targets and treatment options for ccRCC patients, we found a gene named STING, with a known cellular function in clearing viral or bacterial infection, is a novel vulnerability and drug target in ccRCC. In addition, we found a chemical compound that was able to slow down ccRCC cell growth through regulating the novel STING function we found.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2023
- Accession Number
- AD1206976
Entities
People
- Pengda Liu
Organizations
- University of North Carolina at Chapel Hill