Epigenetic Changes and Clinicopathological Characterization of Prostate Cancer from Patients of African Ancestry
Abstract
Prostate cancer is the most common non-skin cancer and the second leading cause of cancer death amongst men in United States. Prostate cancer heath disparities are largely coming from ethnic differences. In particular, men of African ancestry have higher risk of prostate cancer and progression is more aggressive than men of European ancestry. However, the factors and underlying mechanisms that lead to those ethnicity-related disparities are not yet fully understood. Prostate tumor molecular subtypes are defined by genetic alterations and it is reported that prostate molecular subtypes are associated with disease prognosis. However, molecular mechanisms, which are related to aggressiveness of prostate tumors in each prostate tumor molecular subtype, are not clear. Epigenetics enable us to unravel the hidden molecular mechanisms of gene regulation, which can give rise to heterogeneous tumor phenotypes that include aggressiveness of prostate cancer. The proposed study will investigate epigenetic changes linked to aggressive prostate tumors from men of African ancestry by generating new genome-wide epigenome datasets from metastatic and primary prostate tumors and performing multivariate statistical analyses. Moreover, integrating multi-omic datasets, this study will identify key epigenetic changes that are found in aggressive prostate tumors of each prostate tumor molecular subtype. Novel findings and newly uncovered biology of aggressive prostate cancer from the proposed study will facilitate developing biomarkers and treatments for aggressive prostate tumors from men of African ancestry. Moreover, the proposed study will accelerate the development of improved targeted therapeutic tools in the field and further providing benefits to prostate cancer patients.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2022
- Accession Number
- AD1206977
Entities
People
- Suhn K Rhie
Organizations
- University of Southern California