Nuclear Pore Complexes in the Maintenance of Skeletal Muscle Integrity and Function
Abstract
Skeletal muscle homeostasis is the result of proper maintenance of differentiated muscle fibers and continuous repair of muscle tissue by satellite cells. Alterations in both, or either, of these processes results in progressive muscle damage leading to excessive loss of muscle mass and/or to the development of muscular dystrophies. The identification and characterization of the basic regulators of skeletal muscle maintenance is critical to comprehend the mechanisms that lead to the deterioration of muscle integrity, and a necessary step in the development of therapies to enhance muscle performance and treat muscle diseases. In our previous work we discovered that the nuclear pore complex component Nup210 is an important regulator of muscle physiology. Of particular importance for this project, we identified that mice lacking Nup210 show a progressive deterioration of muscle structure and function. Yet, the muscle processes that are affected by the absence of Nup210, and the causes of such muscle alterations are poorly understood.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2023
- Accession Number
- AD1207385
Entities
People
- Maximiliano Dangelo