The Role of Basic Helix-Loop-Helix (bHLH) Transcription Factors in Glioma-Associated Microglia
Abstract
Gliomas are the most common primary brain tumors and result in more years of life lost than does any other tumor. Glioma formation,progression, and over prognosis depend on interactions of tumor cells with other cells in the microenvironment such as CNS resident microglia,tumor-associated macrophages (TAMs) and myeloid-derived suppressor cells (MDSCs) amongst other cells. Microglia are resident macrophages of the CNS that are distributed throughout the CNS where they function as key immune effector cells in health and disease. These cells are in a prime position to detect threats to the CNS and respond by mounting an effective immune response. However, the regulation of the development and function of microglia by transcription factors in health and disease is poorly understood. In glioma microenvironment, microglia interact with neoplastic cells; however, the nature and mediators of these interactions are still poorly understood. Elucidation of the transcriptional regulation of the development and functions of microglia in the glioma microenvironment represents initial steps toward developing anti-tumor immunotherapies and stroma-directed therapies that can be combined with anti-tumor cell targeted therapies. Objective: The overall goal of this project is to investigate how transcription factors regulate the development, function and maintenance of microglia in glioma microenvironment.Specific Aims: The aims of this study are: 1. Elucidation of the effects of the loss of a major transcription factor in microglia on their function in the microenvironment of high grade gliomas. 2. Illumination of the mechanism of actions of this transcription factor in microglia.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2023
- Accession Number
- AD1207676
Entities
People
- Babacar Cisse
Organizations
- Cornell University